LymphedemaV1, Main, Exploration, bibRecord, 00C907

Lymphoscintigraphic Analysis Of Lymphatic Abnormalities In Symptomatic And Asymptomatic Human Filariasis

Identifieur interne : 00C907 ( Main/Exploration ); précédent : 00C906; suivant : 00C908

Lymphoscintigraphic Analysis Of Lymphatic Abnormalities In Symptomatic And Asymptomatic Human Filariasis

Auteurs : David O. Freedman [Royaume-Uni, Brésil] ; Paulo Jose De Almeida Filho [Royaume-Uni, Brésil] ; Stephen Besh [Royaume-Uni, Brésil] ; Maria Carmelita Maia E Silva [Royaume-Uni, Brésil] ; Cynthia Braga [Royaume-Uni, Brésil] ; Amelia Maciel [Royaume-Uni, Brésil]

Source :

Journal of Infectious Diseases [ 0022-1899 ] ; 1994-10.

RBID : ISTEX:7B90114F0FCF219673E7AA2984551CE2EE31E976

Abstract

To obtain high-resolution radionuclide Iymphoscintigraphic images of affected limbs in persons with both symptomatic and asymptomatic filarial infection, 36 volunteers were recruited from a Wuchereria banerolti-endemic area of Recife, Brazil, for a prospective, controlled analysis. Subjects were stratified after determination of serologic and clinical determinants of filarial infection status. Widespread lymphatic abnormalities were found in clinically asymptomatic microfilaremic persons, who had been assumed to have infection but not disease. All patients with clinical manifestations of lymphatic pathology had marked abnormalities. No correlation was found between clinical findings and actual lymphatic function as demonstrated by lymphoscintigraphy. The initial diagnosis of lymphatic filariasis, whether asymptomatic or symptomatic, is based on nonimaging laboratory criteria. After diagnosis, lymphoscintigraphy is a valuable tool for initial assessment of any lymphatic damage. Changes in strategies for therapeutic interventions in asymptomatic microfilaremic persons, who are not usually aggressively treated, may be warranted.

Url:

https://api.istex.fr/document/7B90114F0FCF219673E7AA2984551CE2EE31E976/fulltext/pdf

DOI: 10.1093/infdis/170.4.927

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 003993
to stream Istex, to step Curation: 003993
to stream Istex, to step Checkpoint: 004A02
to stream Main, to step Merge: 00D283
to stream Main, to step Curation: 00C907

Le document en format XML

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<front><div type="abstract">To obtain high-resolution radionuclide Iymphoscintigraphic images of affected limbs in persons with both symptomatic and asymptomatic filarial infection, 36 volunteers were recruited from a Wuchereria banerolti-endemic area of Recife, Brazil, for a prospective, controlled analysis. Subjects were stratified after determination of serologic and clinical determinants of filarial infection status. Widespread lymphatic abnormalities were found in clinically asymptomatic microfilaremic persons, who had been assumed to have infection but not disease. All patients with clinical manifestations of lymphatic pathology had marked abnormalities. No correlation was found between clinical findings and actual lymphatic function as demonstrated by lymphoscintigraphy. The initial diagnosis of lymphatic filariasis, whether asymptomatic or symptomatic, is based on nonimaging laboratory criteria. After diagnosis, lymphoscintigraphy is a valuable tool for initial assessment of any lymphatic damage. Changes in strategies for therapeutic interventions in asymptomatic microfilaremic persons, who are not usually aggressively treated, may be warranted.</div>
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Lymphoscintigraphic Analysis Of Lymphatic Abnormalities In Symptomatic And Asymptomatic Human Filariasis

Lymphoscintigraphic Analysis Of Lymphatic Abnormalities In Symptomatic And Asymptomatic Human Filariasis

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Abstract

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Le document en format XML

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